Department of Biology
Biology Faculty Profile
George H. Jones, Emeritus
Goodrich C. White Professor
george.h.jones@emory.edu
Office Phone: 404-727-0712 | Lab Phone: 404-727-4208
Office Room: Rollins 2001
Office Address: Emory University, Department of Biology, O. Wayne Rollins Research Center, 1510 Clifton Road NE, Atlanta , GA 30322
Lab Room: Rollins 2132

Research Area:
Genetics, Cell, and Developmental Biology

Graduate Program Affiliation:
Microbiology and Molecular Genetics

Degree:

B.S., Harvard University, 1963
Ph.D., University of California, Berkeley, 1968

Mechanism and regulation of antibiotic synthesis in Streptomyces. We are interested in the biochemistry and evolution of RNA degradation pathways in bacteria and the relationship of RNA degradation to antibiotic biosynthesis in Streptomyces. We are particularly interested in (1) the regulation and function of polynucleotide phosphorylase in the synthesis of RNA 3'-tails in Streptomyces; (2) the role of the double strand specific endoribonuclease, RNase III, a product of the absB locus in Streptomyces coelicolor, in regulating antibiotic production; and, (3) the mechanisms of transcript processing in Streptomyces and the role of processing in the regulation of gene expression; and (4) the biochemistry and evolution of RNA polyadenylation in various bacterial species, particularly Bacillus. We utilize biochemical, genetic and bioinformatic approaches to study these systems.


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