Department of Biology
Biology Faculty Profile
John Lucchesi, Emeritus
Asa G. Candler Professor
Office Phone: 404-291-9924 | Lab Phone: 404-727-4946
Office Room: Rollins 1011
Office Address: Emory University, Department of Biology, O. Wayne Rollins Research Center, 1510 Clifton Road NE, Atlanta , GA 30322
Lab Room: Rollins 1071
Lab Website

Research Area:
Genetics, Cell, and Developmental Biology
Population Biology, Evolution, and Ecology

Graduate Program Affiliation:
Biochemistry, Cell & Developmental Biology
Genetics and Molecular Biology
Population Biology, Ecology and Evolution


A.B. (Biology/Chemistry), La Grange College, 1955
M.S. (Zoology/Genetics), University of Georgia, Athens, 1958
Ph.D. (Zoology/Genetics), University of California, Berkley, 1963

In cells DNA is wrapped around nucleosomes (octamers of four 4 different histones). The association of DNA and nucleosomes is unfavorable to the process of transcription and must be modified in order for genes to be activated and for transcription to be initiated. The modifications that result in gene activation are the responsibility of large multi-protein complexes. But activating genes is not sufficient: once transcription has been initiated its rate must be regulated so that gene products are made at the appropriate level. Using Drosophila, and human cell cultures, our laboratory has obtained evidence that this level of regulation is also carried out by multiprotein complexes that share many features with the complexes that initiate gene activity. One of our major experimental goals has been to study the targeting of one of these complexes to its sites of action. The other major goal is to understand its mechanism of action.

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