Ori Department of Biology | Emory University
Department of Biology
Biology Faculty Profile
David Gorkin
Assistant Professor
david.gorkin@emory.edu
Office Room: Rollins 1009
Office Address: Emory University, Department of Biology, O. Wayne Rollins Research Center, 1510 Clifton Road NE, Atlanta , GA 30322
Lab Website

Research Area:
Genetics, Cell, and Developmental Biology
Computational Biology

Degree:

B.A., Boston University, 2004
Ph.D. Johns Hopkins University, 2013

Mammalian development relies on a complex interplay between genetic and epigenetic factors to create trillions of highly specialized cells from the same genetic blueprint. This process is orchestrated in part by gene regulatory sequences encoded in DNA, which in turn are influenced by epigenetic properties including DNA methylation, DNA packaging, and modifications of DNA packaging proteins. Mammalian genomes contain hundreds of epigenetic regulators -- collectively referred to as the “epigenetic machinery” -- which are responsible for reading, writing, and erasing this epigenetic information. Our research seeks to understand how the epigenetic machinery works, and how its malfunction contributes to disease.

 

Current directions in the lab seek to answer the following key questions about the epigenetic machinery:

 

1. What are the specific regulatory sequences and target genes influenced by components of the epigenetic machinery, and in what cell types/contexts? 

 

2. How are components of the epigenetic machinery recruited to specific regions of the genome (e.g. regulatory sequences) in specific cellular contexts?

 

3. By what mechanisms do disease-causing mutations in components of the epigenetic machinery give rise to phenotypes at the molecular, cellular, and organismal levels.

 

To answer these questions, we use a variety of tools including epigenomics, genome-editing, single-cell genomics, and computational biology, with a focus on mouse developmental and human cell culture models.


Copyright © Emory University 2009 - All Rights Reserved | 201 Dowman Drive, Atlanta, Georgia 30322 USA 404.727.6123
EMORY HOME | CONTACT EMORY | EMERGENCY | CAREERS | MAKE A GIFT | ABOUT EMORY'S WEB