Department of Biology
Biology Faculty Profile
Ronald Calabrese
Samuel C. Dobbs Professor
ronald.calabrese@emory.edu
Office Phone: 404-727-0319 | Lab Phone: 404-727-4202
Office Room: Rollins 2113
Office Address: Emory University, Department of Biology, O. Wayne Rollins Research Center, 1510 Clifton Road NE, Atlanta , GA 30322
Lab Room: Rollins 2167
Lab Website

Research Area:
Neuroscience

Graduate Program Affiliation:
Neuroscience

Degree:

B.S., Cornell University , 1969
Ph.D., Stanford University , 1975

Our lab studies the neural circuit that controls the hearts of medicinal leeches. We record the electrical activity of neurons in this circuit with intracellular and extracellular recording techniques. Using voltage clamp techniques, we isolate and characterize the individual ionic currents that contribute to this activity. We also study the biophysics of synaptic transmission and the role of background calcium in synaptic plasticity using Ca imaging. To understand how membrane currents and synaptic transmission interact to produce the activity of the circuit, we simulate the ionic currents and cell connectivity with realistic biophysical models. We also use such models in real time simulation to construct hybrid systems between computer and neuron to analyze circuit and neuronal function. We address the general questions of how rhythmic motor patterns are generated and coordinated by networks of interneurons and how these patterns are used to produce the final pattern of activity in motor neurons that produce functionally coordinated movement.


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