The Calabrese Lab

 HN4 cells 

A pair of HN4 neurons, one real and one simulated.  If you have red-green 3D glasses, you can see the right cell in 3D.
(Cell viewer courtesy Robert Cannon.)


Our lab studies the neural circuit that controls the heart of the medicinal leech. We record the behavior of neurons in this circuit with microelectrodes. Using voltage clamp techniques, we isolate and characterize the individual ionic currents which contribute to this behavior. We study how the structure of these neurons affects their behavior using dynamic imaging and selective dendritic laser ablation. To understand how these currents and structures interact to produce the behavior of the circuit, we simulate the ionic currents and cell connectivity with realistic biophysical models.




Lab Members 



Recommended Reading


Blackmail Photos






Last updated February 8, 2010. Please send comments to adolocm at